CRTC1

 CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.^[5][6][7][8] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands^[9] and various regions of the adult central nervous system.^[10]

CRTC1
Identifiers
Aliases	CRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
External IDs	OMIM: 607536 MGI: 2142523 HomoloGene: 41607 GeneCards: CRTC1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,683,678 bp[1] End 18,782,333 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,382,355 bp[2] End 70,439,579 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • cAMP response element binding protein binding Cellular component • neuronal cell body • cell membrane • dendrite • synapse • cell nucleus • nucleoplasm • cytoplasm • cytosol • nuclear body • GO:0097483, GO:0097481 postsynaptic density • glutamatergic synapse Biological process • positive regulation of CREB transcription factor activity • GO:0022415 viral process • positive regulation of dendrite development • memory • entrainment of circadian clock by photoperiod • protein homotetramerization • positive regulation of long-term synaptic potentiation • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • rhythmic process • regulation of transcription, DNA-templated • energy homeostasis • negative regulation of membrane hyperpolarization • postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23373	382056
Ensembl	ENSG00000105662	ENSMUSG00000003575
UniProt	Q6UUV9	Q68ED7
RefSeq (mRNA)	NM_001098482 NM_015321 NM_025021	NM_001004062
RefSeq (protein)	NP_001091952 NP_056136	NP_001004062
Location (UCSC)	Chr 19: 18.68 – 18.78 Mb	Chr 8: 70.38 – 70.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Not to be confused with mTORC1.

Clinical significanceEdit

Production of CRTC1 is blocked in Alzheimer's disease.^[11] TORC1 might be the target protein in ketamin induced anti-depressent effect via NMDA-antagonisation.

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.