CRKL

 Crk-like protein is a protein that in humans is encoded by the CRKL gene.^[5][6]

CRKL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZX, 2BZY, 2EO3, 2LQN, 2LQW
Identifiers
Aliases	CRKL, CRK like proto-oncogene, adaptor protein
External IDs	OMIM: 602007 MGI: 104686 HomoloGene: 38021 GeneCards: CRKL
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 20,917,407 bp[1] End 20,953,747 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,451,987 bp[2] End 17,487,434 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • signal transducer activity • RNA binding • cadherin binding • phosphotyrosine residue binding • identical protein binding Cellular component • cytoplasm • cytosol • endosome • extracellular exosome • nucleoplasm • neuromuscular junction • macromolecular complex • synapse • extrinsic component of postsynaptic membrane Biological process • animal organ morphogenesis • pattern specification process • JNK cascade • heart development • Ras protein signal transduction • GO:0007243 intracellular signal transduction • blood vessel development • parathyroid gland development • anterior/posterior pattern specification • positive regulation of cell proliferation • activation of MAPKK activity • thymus development • positive regulation of substrate adhesion-dependent cell spreading • activation of MAPK activity • regulation of cell growth • urogenital system development • neuron migration • B cell apoptotic process • negative regulation of protein phosphorylation • positive regulation of protein phosphorylation • regulation of leukocyte migration • outflow tract morphogenesis • lipid metabolism • spermatogenesis • single fertilization • synapse assembly • fibroblast growth factor receptor signaling pathway • male gonad development • regulation of gene expression • negative regulation of gene expression • dendrite development • cytokine-mediated signaling pathway • hippocampus development • cerebral cortex development • establishment of cell polarity • regulation of cell adhesion mediated by integrin • helper T cell diapedesis • cellular response to drug • reelin-mediated signaling pathway • positive regulation of Ras protein signal transduction • retinoic acid receptor signaling pathway • regulation of dendrite development • T cell receptor signaling pathway • cell chemotaxis • pharynx development • positive regulation of ERK1 and ERK2 cascade • cellular response to transforming growth factor beta stimulus • response to fibroblast growth factor • endothelin receptor signaling pathway • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • acetylcholine receptor signaling pathway • cerebellar neuron development • cellular response to interleukin-7 • positive regulation of glial cell migration • regulation of skeletal muscle acetylcholine-gated channel clustering • cranial skeletal system development • regulation of T cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1399	12929
Ensembl	ENSG00000099942	ENSMUSG00000006134
UniProt	P46109	P47941
RefSeq (mRNA)	NM_005207	NM_001277231 NM_007764
RefSeq (protein)	NP_005198	NP_001264160 NP_031790
Location (UCSC)	Chr 22: 20.92 – 20.95 Mb	Chr 16: 17.45 – 17.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.^[7]

CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.^[8][9]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.