CD6

 CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.^[5][6]

CD6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A2E
Identifiers
Aliases	CD6, TP120, CD6 molecule
External IDs	OMIM: 186720 MGI: 103566 HomoloGene: 4893 GeneCards: CD6
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.2 Start 60,971,680 bp[1] End 61,020,377 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 7.16 cM Start 10,789,341 bp[2] End 10,830,058 bp[2]
Gene ontology Molecular function • lipopolysaccharide binding • lipoteichoic acid binding • scavenger receptor activity • GO:0001948 protein binding • identical protein binding Cellular component • integral component of membrane • membrane • intrinsic component of plasma membrane • cell membrane • integral component of plasma membrane • T cell receptor complex • extracellular region • immunological synapse • external side of plasma membrane Biological process • positive regulation of cytokine production involved in inflammatory response • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • adaptive immune response • immune system process • acute inflammatory response to antigenic stimulus • receptor-mediated endocytosis • response to lipopolysaccharide • cell adhesion • positive regulation of T cell proliferation • innate immune system • immunological synapse formation • lipopolysaccharide-mediated signaling pathway • vesicle-mediated transport • endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	923	12511
Ensembl	ENSG00000013725	ENSMUSG00000024670
UniProt	P30203	Q61003
RefSeq (mRNA)	NM_001254750 NM_001254751 NM_006725	NM_001037801 NM_009852
RefSeq (protein)	NP_001241679 NP_001241680 NP_006716	NP_001032890 NP_033982
Location (UCSC)	Chr 11: 60.97 – 61.02 Mb	Chr 19: 10.79 – 10.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.^[5]

Clinical significanceEdit

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.^[7][8]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.