Cathepsin A

 Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene.^[5]

CTSA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IVY, 3BP4, 3BP7, 3BXN, 4AZ0, 4AZ3, 4CI9, 4CIA, 4CIB, 4MWS, 4MWT
Identifiers
Aliases	CTSA, GLB2, GSL, NGBE, PPCA, PPGB, cathepsin A
External IDs	OMIM: 613111 MGI: 97748 HomoloGene: 80163 GeneCards: CTSA
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,890,144 bp[1] End 45,898,820 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 85.27 cM Start 164,832,873 bp[2] End 164,841,032 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • carboxypeptidase activity • GO:0010577 enzyme activator activity • hydrolase activity • exo-alpha-sialidase activity • serine-type carboxypeptidase activity Cellular component • membrane • intracellular membrane-bounded organelle • nucleoplasm • lysosomal lumen • endoplasmic reticulum • lysosome • lumenal side of lysosomal membrane • extracellular exosome • extracellular region • azurophil granule lumen Biological process • regulation of protein stability • glycosphingolipid metabolic process • proteolysis • regulation of chaperone-mediated autophagy • proteolysis involved in cellular protein catabolic process • intracellular protein transport • GO:0048554 positive regulation of catalytic activity • neutrophil degranulation • negative regulation of chaperone-mediated autophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5476	19025
Ensembl	ENSG00000064601	ENSMUSG00000017760
UniProt	P10619	P16675
RefSeq (mRNA)	NM_001167594 NM_000308 NM_001127695	NM_001038492 NM_008906
RefSeq (protein)	NP_000299 NP_001121167 NP_001161066	NP_001033581 NP_032932
Location (UCSC)	Chr 20: 45.89 – 45.9 Mb	Chr 2: 164.83 – 164.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.^[6]

Clinical significanceEdit

Deficiencies in this gene are linked to multiple forms of galactosialidosis.^[5]

InteractionsEdit

Cathepsin A has been shown to interact with NEU1.^[7]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.