Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.[5][6]
| BMX |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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2EKX, 2YS2, 3SXR, 3SXS |
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| Identifiers |
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| Aliases | BMX, ETK, PSCTK2, PSCTK3, BMX non-receptor tyrosine kinase |
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| External IDs | OMIM: 300101 MGI: 1101778 HomoloGene: 20411 GeneCards: BMX |
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| Gene location (Human) |
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 | | Chr. | X chromosome (human)[1] |
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| | Band | Xp22.2 | Start | 15,464,246 bp[1] |
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| End | 15,556,529 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | X chromosome (mouse)[2] |
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| | Band | X|X F5 | Start | 164,192,842 bp[2] |
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| End | 164,258,193 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • transferase activity
• nucleotide binding
• protein kinase activity
• signal transducer activity
• metal ion binding
• kinase activity
• GO:0001948 protein binding
• protein tyrosine kinase activity
• receptor binding
• ATP binding
• non-membrane spanning protein tyrosine kinase activity
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| Cellular component | • cytoplasm
• cytosol
• extrinsic component of cytoplasmic side of plasma membrane
• ruffle membrane
• nucleoplasm
• cell membrane
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| Biological process | • GO:0007243 intracellular signal transduction
• phosphorylation
• NK T cell differentiation
• transmembrane receptor protein tyrosine kinase signaling pathway
• protein phosphorylation
• cell adhesion
• regulation of cell proliferation
• peptidyl-tyrosine autophosphorylation
• autophosphorylation
• mesoderm development
• innate immune system
• signal transduction
• apoptotic process
• phosphatidylinositol biosynthetic process
• adaptive immune response
• B cell receptor signaling pathway
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001721
NM_203281
NM_001320866 |
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| RefSeq (protein) | |
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NP_001307795
NP_001712
NP_975010 |
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| Location (UCSC) | Chr X: 15.46 – 15.56 Mb | Chr X: 164.19 – 164.26 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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FunctionEditTyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[6]
