Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene.[5][6]
| AQP5 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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3D9S, 5C5X, 5DYE |
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| Identifiers |
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| Aliases | AQP5, AQP-5, PPKB, aquaporin 5 |
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| External IDs | OMIM: 600442 MGI: 106215 HomoloGene: 20398 GeneCards: AQP5 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 12 (human)[1] |
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| | Band | 12q13.12 | Start | 49,961,872 bp[1] |
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| End | 49,965,682 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 15 (mouse)[2] |
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| | Band | 15 F1|15 56.13 cM | Start | 99,590,782 bp[2] |
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| End | 99,594,829 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • transporter activity
• GO:0001948 protein binding
• water channel activity
• identical protein binding
• channel activity
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| Cellular component | • integral component of membrane
• membrane
• cell membrane
• integral component of plasma membrane
• microvilli
• basal plasma membrane
• apical plasma membrane
• endoplasmic reticulum
• extracellular exosome
• cytoplasmic vesicle membrane
• cytoplasmic vesicle
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| Biological process | • excretion
• water transport
• pancreatic juice secretion
• salivation
• odontogenesis
• ion transmembrane transport
• camera-type eye morphogenesis
• carbon dioxide transport
• transport
• transmembrane transport
• protein homotetramerization
• cellular hypotonic response
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 12: 49.96 – 49.97 Mb | Chr 15: 99.59 – 99.59 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions.[6] AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.[6]
