Angiopoietin-related protein 2

 Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene.^[5][6]

ANGPTL2
Identifiers
Aliases	ANGPTL2, ARP2, HARP, angiopoietin like 2
External IDs	OMIM: 605001 MGI: 1347002 HomoloGene: 22695 GeneCards: ANGPTL2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 127,087,348 bp[1] End 127,122,635 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 33,216,069 bp[2] End 33,247,717 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • GO:0001948 protein binding Cellular component • extracellular region • extracellular exosome • extracellular • collagen-containing extracellular matrix Biological process • multicellular organism development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23452	26360
Ensembl	ENSG00000136859	ENSMUSG00000004105
UniProt	Q9UKU9	Q9R045
RefSeq (mRNA)	NM_012098	NM_011923
RefSeq (protein)	NP_036230	NP_036053
Location (UCSC)	Chr 9: 127.09 – 127.12 Mb	Chr 2: 33.22 – 33.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. ANGPTL2 has a role also in angiogenesis, in tissue repair, in obesity, in atherosclerotic diseases and finally in carcinogenesis.^[7]

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action.^[6]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.