Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.[5][6]
| AKR1C1 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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1MRQ, 3C3U, 3GUG, 3NTY, 4YVP |
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| Identifiers |
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| Aliases | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1 member C1 |
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| External IDs | OMIM: 600449 MGI: 1924587 HomoloGene: 134114 GeneCards: AKR1C1 |
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| EC number | 1.1.1.112 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 10 (human)[1] |
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| | Band | 10p15.1 | Start | 4,963,253 bp[1] |
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| End | 4,983,283 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 13 (mouse)[2] |
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| | Band | 13|13 A1 | Start | 4,574,075 bp[2] |
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| End | 4,586,541 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
• alditol:NADP+ 1-oxidoreductase activity
• indanol dehydrogenase activity
• aldo-keto reductase (NADP) activity
• 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
• androsterone dehydrogenase (B-specific) activity
• phenanthrene 9,10-monooxygenase activity
• oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
• bile acid binding
• GO:0001948 protein binding
• carboxylic acid binding
• oxidoreductase activity
• ketosteroid monooxygenase activity
• alcohol dehydrogenase (NADP+) activity
• steroid dehydrogenase activity
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| Cellular component | • cytoplasm
• cytosol
• extracellular exosome
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| Biological process | • cellular response to jasmonic acid stimulus
• epithelial cell differentiation
• daunorubicin metabolic process
• doxorubicin metabolic process
• progesterone metabolic process
• bile acid metabolic process
• digestion
• retinal metabolic process
• retinoid metabolic process
• response to organophosphorus
• bile acid and bile salt transport
• intestinal cholesterol absorption
• xenobiotic metabolic process
• cholesterol homeostasis
• protein homooligomerization
• oxidation-reduction process
• steroid metabolic process
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 10: 4.96 – 4.98 Mb | Chr 13: 4.57 – 4.59 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.[6]
