Adapter molecule crk

 Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.^[5]

CRK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JU5, 2DVJ, 2EYV, 2EYW, 2EYX, 2EYY, 2EYZ, 2MS4
Identifiers
Aliases	CRK, CRKII, p38, v-crk avian sarcoma virus CT10 oncogene homolog, CRK proto-oncogene, adaptor protein
External IDs	OMIM: 164762 MGI: 88508 HomoloGene: 81850 GeneCards: CRK
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 1,420,689 bp[1] End 1,463,162 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.92 cM Start 75,679,259 bp[2] End 75,706,908 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding, bridging • protein domain specific binding • ephrin receptor binding • GO:0001948 protein binding • enzyme binding • insulin-like growth factor receptor binding • cytoskeletal protein binding • scaffold protein binding • phosphotyrosine residue binding • SH3 domain binding • SH2 domain binding • protein self-association • protein phosphorylated amino acid binding • protein tyrosine kinase binding Cellular component • cytoplasm • cytosol • membrane • cell membrane • actin cytoskeleton • extracellular exosome • cell nucleus • membrane raft • macromolecular complex Biological process • activation of MAPKK activity • Fc-gamma receptor signaling pathway involved in phagocytosis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • ephrin receptor signaling pathway • regulation of transcription from RNA polymerase II promoter • regulation of Rac protein signal transduction • vascular endothelial growth factor receptor signaling pathway • regulation of actin cytoskeleton organization • positive regulation of substrate adhesion-dependent cell spreading • response to yeast • positive regulation of smooth muscle cell migration • response to hepatocyte growth factor • response to hydrogen peroxide • negative regulation of natural killer cell mediated cytotoxicity • cellular response to transforming growth factor beta stimulus • cellular response to nitric oxide • response to peptide • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • cellular response to endothelin • regulation of cell shape • regulation of signal transduction • positive regulation of cell growth • regulation of protein binding • regulation of wound healing • negative regulation of wound healing • response to cholecystokinin • regulation of cell motility • negative regulation of cell motility • neuron migration • regulation of leukocyte migration • lipid metabolism • dendrite development • cytokine-mediated signaling pathway • hippocampus development • cerebral cortex development • establishment of cell polarity • regulation of cell adhesion mediated by integrin • helper T cell diapedesis • reelin-mediated signaling pathway • regulation of dendrite development • cell chemotaxis • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • cerebellar neuron development • regulation of T cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1398	12928
Ensembl	ENSG00000167193	ENSMUSG00000017776
UniProt	P46108	Q64010
RefSeq (mRNA)	NM_016823 NM_005206	NM_001277219 NM_001277221 NM_133656
RefSeq (protein)	NP_005197 NP_058431	NP_001264148 NP_001264150 NP_598417
Location (UCSC)	Chr 17: 1.42 – 1.46 Mb	Chr 11: 75.68 – 75.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The CRK protein participates in the Reelin signaling cascade downstream of DAB1.^[6][7]

FunctionEdit

Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.^[8]

Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.^[6][7]

v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk.^[9] The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells.^[10]

Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.